Promethazine Symptoms and symptoms of overdosage with promethazine vary from moderate depression from the central anxious method and cardiovascular method to profound hypotension, respiratory melancholy, unconsciousness and unexpected death.
In the event the patient develops these indications or indicators, elevate the dose to the past amount and taper a lot more slowly and gradually, either by expanding the interval amongst decreases, reducing the amount of change in dose, or both equally.
To reduce your possibility, your physician should have you take the smallest dose that works, and get it for that shortest feasible time. See also Ways to Use portion For more info about dependancy.
Due to danger of respiratory depression, avoid the usage of opioid antitussives, such as Promethazine HCl and Codeine Phosphate Oral Alternative in people with compromised respiratory perform, patients vulnerable to respiratory failure, As well as in elderly, cachectic, or debilitated people.
Bodily dependence, the issue in which ongoing administration on the drug is necessary to circumvent the appearance of the withdrawal syndrome, assumes clinically significant proportions only just after many months of ongoing oral opioid use, although some gentle diploma of Actual physical dependence could establish soon after a few days of opioid therapy.
In people acquiring MAO inhibitors, an First smaller test dose is recommended to allow observation of any abnormal narcotic consequences or MAOI interaction.
, ritonavir) or discontinuation of a cytochrome P450 3A4 inducer like rifampin, carbamazepine, and phenytoin, may perhaps result in an increase in codeine plasma concentrations with subsequently higher metabolism by cytochrome P450 2D6, leading to increased morphine concentrations, which could improve or lengthen adverse reactions and may lead to possibly fatal respiratory despair.
Stimulation could be apparent, particularly in little ones and geriatric clients. Convulsions might not often come about. A paradoxical response has been described in small children receiving single doses of seventy five mg to one hundred twenty five mg orally, characterized by hyperexcitability and nightmares.
Bluish lips or skin chills clay-colored stools cold sweats confusion cough dim urine minimize in the frequency of urination lessen in the urine volume diarrhea tricky or troubled breathing issues in passing urine (dribbling) dizziness dizziness, faintness, or lightheadedness when obtaining up from lying or sitting situation quick, pounding, or irregular heartbeat or pulse sensation of warmth fever headache superior fever hives or welts, itching, or rash amplified sweating irregular, speedy or sluggish, or shallow respiration big, hive-like swelling over the encounter, eyelids, lips, tongue, throat, fingers, legs, ft, or sexual intercourse organs loss of hunger loss of bladder Management nausea noisy respiratory not respiratory agonizing urination pale or blue lips, fingernails, or skin rectal bleeding redness on the facial area, neck, arms, and occasionally, higher chest redness in the skin seeing, hearing, or sensation points that aren't there seizures significant muscle stiffness shakiness in the legs, arms, or fingers stomach suffering sweating tightness in the Promethazine codeine syrup chest tiredness trembling or shaking on the fingers or feet uncomfortable breath odor uncommon tiredness or weakness unusually pale pores and skin vomiting of blood yellow eyes or skin Get emergency enable instantly if any of the subsequent signs of overdose happen:
If this SPL incorporates inactivated NDCs shown by the FDA initiated compliance motion, they will be specified as such.
This medication could contain sugar and/or Liquor. Caution is advised In case you have diabetes, Alcoholic beverages dependence, or liver condition. Inquire your health care provider or pharmacist about employing this merchandise securely.
Small children ought to be supervised for the duration of bicycle Using along with other quite possibly dangerous routines to prevent injury. Restrict alcoholic beverages. Speak with your medical doctor If you're working with cannabis (cannabis).
Codeine has very good antitussive action, Even though below that of morphine at equivalent doses. It truly is Employed in desire to morphine, because side effects are rare at the standard antitussive dose of codeine.
To help avoid withdrawal, your physician may decreased your dose little by little. Withdrawal is much more probable Should you have applied this medication for a long time (various months) or in significant doses. Notify your health care provider or pharmacist instantly When you have withdrawal.